A study published in Crit_Care finds that biomarkers of endothelial dysfunction are independently associated with risk of severe sepsis-associated kidney injury and demonstrate variable responses across pediatric sepsis mortality.
]. Urine output data were not available for all patients in the cohort and therefore not included. All patients receiving RRT were considered to have severe AKI. The primary outcome of interest was the presence of severe SA-AKI, based on serum creatinine criteria alone, on day 3 of septic shock—a clinically relevant time point in AKI research []. The outcome is henceforth annotated as Day 3 SA-AKI SCr.
We subsequently derived a new CART model to optimize risk prediction among the subset of patients with high- or intermediate-PERSEVERE-II mortality risk using published approaches [= 1 standard error of minimum misclassification cost was chosen to select the optimal tree. Class probability method and tenfold cross-validation was used for CART analyses. Patients were categorized as high- versus low- D3 SA-AKI SCr risk categories based on output of the model.
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