A study published in BMCGastroEnterol discusses a novel 5-gene signature as a prognostic assessment model for pancreatic cancer patients.
), the expression data was normalized by RMA. The expression levels of TCGA-PAAD and GTEx were rescaled using FPKM as the unit of measure for subsequent analyses. Differentially expressed genes was identified using Limma package in R. The cut-off value was set to |logFC|> 1 andA, there are 178 tumor samples and 4 normal samples in TCGA-PAAD dataset.
167 normal samples in GTEx-PAAD dataset, 45 tumor samples and 45 normal samples in GSE28735, 69 tumor samples and 61 normal samples in GSE62452. The TCGA-PAAD and GTEx-PAAD are RNA-seq data, the expression data in them were normalized by FPKM. GSE28735 and GSE62452 share the same platform which ID is GPL6244. The expression data in the array chips was normalized into RAM. Limma R package was used for differential expression analysis.
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Association between calf circumference and incontinence in Chinese elderly - BMC Public HealthBackground The objective of this study was to analyze the association between calf circumference and incontinence in Chinese elderly, and to find out the maximal cut-off point by gender for the use of calf circumference in screening for incontinence. Methods In this study, participants were from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS). The maximal calf circumference cut-off point and other incontinence-related risk factors were explored using receiver operating characteristic (ROC) curves and logistic regression analysis. Results The study included 14,989 elderly people (6,516 males and 8,473 females) over 60. The prevalence of incontinence in elderly males was 5.23% (341/6,516), significantly lower than females, which was 8.31% (704/8,473) (p | 0.001). There was no correlation between calf circumference | 34 cm in males and | 33 cm in females and incontinence after adjusting the confounders. We further stratified by gender to predict incontinence in elderly based on the Youden index of ROC curves. We found the association between calf circumference and incontinence was the strongest when the cut-off points were | 28.5 cm for males and | 26.5 cm for females, with an odds rate (OR) value of 1.620 (male, 95%CI: 1.197–2.288) and 1.292 (female, 95%CI: 1.044–1.600) after adjusting the covariates, respectively. Conclusions Our study suggests that calf circumference | 28.5 cm in males and | 26.5 cm in females is a risk factor for incontinence in the Chinese elderly population. Calf circumference should be measured in routine physical examination, and timely interventions should be made to reduce the risk of incontinence in subjects with calf circumference less than the threshold.
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A 50-year-old refugee woman with a lithopedion and a lifetime of trauma: a case report - BMC Women's HealthBackground Lithopedion is a term that refers to a fetus that has calcified or changed to bone. The calcification may involve the fetus, membranes, placenta, or any combination of these structures. It is an extremely rare complication of pregnancy and can remain asymptomatic or present with gastrointestinal and/or genitourinary symptoms. Case presentation A 50-year-old Congolese refugee with a nine-year history of retained fetus after a fetal demise was resettled to the United States (U.S.). She had chronic symptoms of abdominal pain and discomfort, dyspepsia, and gurgling sensation after eating. She experienced stigmatization from healthcare professionals in Tanzania at the time of the fetal demise and subsequently avoided healthcare interaction whenever possible. Upon arrival to the U.S., evaluation of her abdominal mass included abdominopelvic imaging which confirmed the diagnosis of lithopedion. She was referred to gynecologic oncology for surgical consultation given intermittent bowel obstruction from underlying abdominal mass. However, she declined intervention due to fear of surgery and elected for symptom monitoring. Unfortunately, she passed away due to severe malnutrition in the context of recurrent bowel obstruction due to the lithopedion and continued fear of seeking medical care. Conclusion This case demonstrated a rare medical phenomenon and the impact of medical distrust, poor health awareness, and limited access to healthcare among populations most likely to be affected by a lithopedion. This case highlighted the need for a community care model to bridge the gap between the healthcare team and newly resettled refugees.
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Needs-based triggers for timely referral to palliative care for older adults severely affected by noncancer conditions: a systematic review and narrative synthesis - BMC Palliative CareBackground Older people with noncancer conditions are less likely to be referred to palliative care services due to the inherent uncertain disease trajectory and a lack of standardised referral criteria. For older adults with noncancer conditions where prognostic estimation is unpredictable, needs-based criteria are likely more suitable. Eligibility criteria for participation in clinical trials on palliative care could inform a needs-based criteria. This review aimed to identify and synthesise eligibility criteria for trials in palliative care to construct a needs-based set of triggers for timely referral to palliative care for older adults severely affected by noncancer conditions. Methods A systematic narrative review of published trials of palliative care service level interventions for older adults with noncancer conditions. Electronic databases Medline, Embase, CINAHL, PsycINFO, CENTRAL, and ClinicalTrials.gov. were searched from inception to June 2022. We included all types of randomised controlled trials. We selected trials that reported eligibility criteria for palliative care involvement for older adults with noncancer conditions, where | 50% of the population was aged ≥ 65 years. The methodological quality of the included studies was assessed using a revised Cochrane risk-of-bias tool for randomized trials. Descriptive analysis and narrative synthesis provided descriptions of the patterns and appraised the applicability of included trial eligibility criteria to identify patients likely to benefit from receiving palliative care. Results 27 randomised controlled trials met eligibility out of 9,584 papers. We identified six major domains of trial eligibility criteria in three categories, needs-based, time-based and medical history-based criteria. Needs-based criteria were composed of symptoms, functional status, and quality of life criteria. The major trial eligibility criteria were diagnostic criteria (n = 26, 96%), followed by medical history-based criteria
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Mum wins battle for fresh inquest into disabled daughter's deathBREAKING: The mother of Jodey Whiting, a housebound disabled woman who killed herself after her benefits were cut, has won a Court of Appeal bid for a fresh inquest into her daughter’s death.
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Breast cancer gene linked to Orkney islandsGene variant known to increase risk of breast and ovarian cancer identified in people with Orkney islands heritage
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How Merseyside health staff are cutting down NHS wait lists with artificial intelligence🩺 Clinical leaders in Cheshire and Merseyside have been using machine learning to help surgeons prioritise waiting lists, reducing bureaucracy and freeing up consultants’ time to help clear the backlog PMGallagher1 reports:
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