Dan G. Duda, DMD, PhD, of the Edwin L.
Massachusetts General Hospital Dec 14 2024 Steele Laboratories for Tumor Biology and Department of Radiation Oncology at Massachusetts General Hospital , is the corresponding author of a paper published in Cancer Immunology Research , "Combination CXCR4 and PD1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma ." Immunotherapy has revolutionized the management of cancer, including liver malignancies.
In this study, we tested a combination blockade of PD1, a protein on the surface of immune cells that can suppress the immune system's ability to fight cancer, and CXCR4. This study tested the effect of specifically blocking CXCR4 on standard anti-PD1 immunotherapy in liver cancer models. Most previous studies and clinical trials tested AMD3100, a small-molecule antagonist of CXCR4, which has a short half-life and a complex mechanism of action.
Immunotherapy Liver Liver Cancer Research Antibodies Carcinoma Cell CXCL12 Dendritic Cell Hepatocellular Carcinoma Hospital Immune System Immunology Oncology Tumor
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