Scientists created four cannabis-derived CBN analogs (chemical look-a-likes) with enhanced neuroprotective properties and potential for therapeutic application in neurological disorders like Alzheimer's, Parkinson's, and traumatic brain injury.
Scientists uncover novel cannabinol neuroprotective properties and discover promising cannabinol analogs for potential future therapeutic application in traumatic brain injury, Alzheimer's, and Parkinson'sScientists created four cannabis-derived CBN analogs with enhanced neuroprotective properties and potential for therapeutic application in neurological disorders like Alzheimer's, Parkinson's, and traumatic brain injury.
"Not only does CBN have neuroprotective properties, but its derivatives have the potential to become novel therapeutics for various neurological disorders," says Research Professor Pamela Maher, senior author of the study."We were able to pinpoint the active groups in CBN that are doing that neuroprotection, then improve them to create derivative compounds that have greater neuroprotective ability and drug-like efficacy.
First, they broke CBN into small fragments and observed which of those fragments were the most effective neuroprotectors by chemically analyzing the fragment's properties. Second, they designed and constructed four novel CBN analogs -- chemical look-alikes -- in which those fragments were amplified, then moved them on to drug screening.
"Our findings help demonstrate the therapeutic potential of CBN, as well as the scientific opportunity we have to replicate and refine its drug-like properties," says Maher."Could we one day give this CBN analog to football players the day before a big game, or to car accident survivors as they arrive in the hospital? We're excited to see how effective these compounds might be in protecting the brain from further damage.
The work was supported by the Paul F. Glenn Center for Biology of Aging Research at the Salk Institute, the Bundy Foundation, the Shiley Foundation, the National Institutes of Health , and the Helmsley Center for Genomic Medicine.Chicago
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