A UCLA-led study has found treatments that reduce the risk of being diagnosed with a cancer recurrence based on rising prostate-specific antigen (PSA) levels after radiotherapy, commonly referred to as biochemical recurrence, do not necessarily improve a patient's long-term overall survival.
The team of investigators found that while biochemical recurrence was associated with a higher risk of death, it still did not meet the criteria to be a reliable surrogate endpoint for overall survival. As defined by the FDA, a clinical outcome directly measures whether people in a trial feel or function better, or live longer. A surrogate endpoint is a specific, relatively early outcome that reliably predicts for a clinical outcome that occurs in the longer-term.
"One reason for our finding could be that many patients in the study died from causes unrelated to prostate cancer," said Dr.
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