Study suggests strong sense of purpose in life promotes cognitive resilience among middle-aged adults
]). With this aim, we used the “visual binning” function from the SPSS, which divides all the included subjects according to a specified number of cut points. The option “equal percentiles based on scanned cases” was used to create 5 sub-groups: Q1 , Q2 , Q3 , Q4 , and Q5 . We later conducted analyses focusing on the extreme groups: the Q1, named lower PiL group, and the Q5, named higher PiL group. These two groups shaped our sample of interest, conformed by 246 individuals.
Neuropsychological status and WMLs did not differ between the HP and LP groups . However, the slopes between the groups were significantly different in the association between EFc and WMLs (
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MiR-3180 inhibits hepatocellular carcinoma growth and metastasis by targeting lipid synthesis and uptake - Cancer Cell InternationalPurpose Reprogrammed lipid metabolism is a hallmark of cancer that provides energy, materials, and signaling molecules for rapid cancer cell growth. Cancer cells acquire fatty acids primarily through de novo synthesis and uptake. Targeting altered lipid metabolic pathways is a promising anticancer strategy. However, their regulators have not been fully investigated, especially those targeting both synthesis and uptake. Methods Immunohistochemistry was performed on samples from patients with hepatocellular carcinoma (HCC) to establish the correlation between miR-3180, stearoyl-CoA desaturase-1 (SCD1), and CD36 expression, quantified via qRT-PCR and western blotting. The correlation was analyzed using a luciferase reporter assay. Cell proliferation, migration, and invasion were analyzed using CCK-8, wound healing, and transwell assays, respectively. Oil Red O staining and flow cytometry were used to detect lipids. Triglycerides and cholesterol levels were analyzed using a reagent test kit. CY3-labeled oleic acid transport was analyzed using an oleic acid transport assay. Tumor growth and metastasis were detected in vivo in a xenograft mouse model. Results MiR-3180 suppressed de novo fatty acid synthesis and uptake by targeting the key lipid synthesis enzyme SCD1 and key lipid transporter CD36. MiR-3180 suppressed HCC cell proliferation, migration, and invasion in an SCD1- and CD36-dependent manner in vitro. The mouse model demonstrated that miR-3180 inhibits HCC tumor growth and metastasis by inhibiting SCD1- and CD36-mediated de novo fatty acid synthesis and uptake. MiR-3180 expression was downregulated in HCC tissues and negatively correlated with SCD1 and CD36 levels. Patients with high miR-3180 levels showed better prognosis than those with low levels. Conclusions Our investigation indicates that miR-3180 is a critical regulator involved in de novo fatty acid synthesis and uptake, which inhibits HCC tumor growth and metastasis by suppressing SCD1 and CD36. Therefo
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