Python's remarkable physiology could lead to new medical breakthroughs

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Python's remarkable physiology could lead to new medical breakthroughs
FibrosisGenesMetabolism
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Researchers fed pythons who had fasted for 28 days a meal of 25% of their body weight and compared them to snakes who had not been fed.

University of Colorado at BoulderAug 22 2024 In the first 24 hours after a python devours its massive prey, its heart grows 25%, its cardiac tissue softens dramatically, and the organ squeezes harder and harder to more than double its pulse. Meanwhile, a vast collection of specialized genes kicks into action to help boost the snake's metabolism fortyfold.

Leslie Leinwand, Study Senior Author and Professor, Molecular, Cellular, and Developmental Biology, University of Colorado BoulderLeinwand first started studying pythons nearly two decades ago, and her lab remains one of the few in the world looking to the constricting, non-venomous reptiles for clues to improve human health.

There are two kinds of heart growth in humans, explains Leinwand: Healthy, like the kind that comes with chronic endurance exercise, and unhealthy, like the kind that comes with disease.Related StoriesHer previous work has shown that over the course of about a week to 10 days after a meal, python hearts get much bigger, their heart rate doubles, and their bloodstream turns milky white with circulating fats which, surprisingly, nourish rather than harm their heart tissue.

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