Protein imbalances that increase brain cell excitability may explain why individuals with Alzheimer's disease (AD) who also experience seizures demonstrate more rapid cognitive decline than those who do not experience seizures.
May 2 2024University of Pennsylvania School of Medicine Protein imbalances that increase brain cell excitability may explain why individuals with Alzheimer's disease who also experience seizures demonstrate more rapid cognitive decline than those who do not experience seizures. These imbalances may be present in the brains of individuals before the onset of AD symptoms.
Previous research has shown similar brain activity in individuals with AD who experience epilepsy. Additionally, many individuals with AD have also experienced at least one seizure, and previous research has shown that these seizures cause a more rapid progression of the disease, and worsen cognitive impairment, like trouble with memory or learning. However, researchers have not been able to identify the underlying connections between AD and seizures.
In this study, researchers evaluated post-mortem tissue from people with AD who also experienced at least one seizure and found that certain forms of these neurotransmitters were dysregulated. These neurons in these individuals exhibited increased excitability and suppressed inhibition, which result in the brain sending more signals between neurons than it needs to, a state that researchers refer to as a "hyperactive brain.
Alzheimer's Disease Brain Brain Cell Cell Cognitive Function Epilepsy Hospital Medicine Neurology Neurons Protein Rapamycin Research Seizure
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