Comprehensive review synthesizes current knowledge on post-orgasmic illness syndrome (POIS), a rare condition marked by a range of symptoms following ejaculation, highlighting the need for further research to understand its causes and develop effective treatments.
By Priyanjana Pramanik, MSc.Mar 17 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent review article published in the International Journal of Impotence Research, researchers synthesized the current knowledge of post-orgasmic illness syndrome , a rare condition about which little is known.
Seven symptom clusters have been proposed to diagnose POIS: rash, throat symptoms, headache, irritation, poor concentration, myalgia, itchy eyes, nasal congestion, fever, and fatigue. Fatigue appears in nearly 70% of patients, while rashes are rare, appearing in only 2.4%. However, nearly half of the patients did not have symptoms after every ejaculation.
Another theory is that endogenous opioids are depleted after ejaculation, leading to symptoms. There could also be underlying autoimmune causes in which the urethra’s antigen-presenting cells stimulate the activation of T-cells when they recognize peptides in the semen. A similar condition in women could involve female prostatic tissue in the upper vagina.
Alpha-blockers have been associated with improvements, as has the treatment of concomitant testosterone deficiency. Human chorionic gonadotrophin resolved symptoms in one study included hypogonadal men. Modulating the immune system and non-steroidal anti-inflammatory drugs have also shown benefits.
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