In this interview, AZoNano speaks with Dr. George Heath from the University of Leeds, UK, about the fundamental principles of Atomic Force Microscopy (AFM), integration with advanced optical microscopy, and relevant applications. He also discusses his research utilizing the NanoRacer.
From Bruker Bio AFM May 16 2024Reviewed by Emily Magee Thought LeaderDr. George HeathUniversity Academic FellowUniversity of Leeds In this interview, AZoNano speaks with Dr. George Heath from the University of Leeds, UK, about the fundamental principles of Atomic Force Microscopy , integration with advanced optical microscopy, and relevant applications. He also discusses his research utilizing the NanoRacer high-speed atomic force microscope to examine protein dynamics.
How do advancements in high-speed AFM, particularly with the NanoRacer, address the limitations of standard AFM in terms of spatial and temporal resolution? Advancements in high-speed AFM, particularly with the NanoRacer, address the limitations of standard AFM by significantly improving spatial and temporal resolution. Traditional AFM techniques often struggle with slow scanning speeds and limited resolution, making it challenging to observe dynamic processes in real-time.
Can you provide examples of dynamic biological processes successfully studied using high-speed AFM, particularly with the NanoRacer? High-speed AFM has been instrumental in studying various dynamic biological processes. One notable study involved observing the dynamics of Myosin V motor protein walking along actin filaments. This study revealed the stepping mechanism of Myosin V, providing insights into how motor proteins move and interact with their cellular environment.
You developed a new image analysis tool, NanoLocz. Could you explain how it handles the extensive data generated by high-speed AFM observations? NanoLocz, our freely available new image analysis tool, addresses the challenge of handling extensive data generated by high-speed AFM observations through several key features. First, it allows for easy data import by supporting all AFM file formats, ensuring compatibility with various high-speed AFM systems.
Traditionally, the structure of the BRCA1-BARD1 complex was challenging to elucidate using techniques like cryo-electron microscopy or X-Ray crystallography due to its inherent flexibility. However, high-speed AFM with the NanoRacer allowed researchers to directly visualize the dynamic interactions between BRCA1-BARD1 and DNA in real-time.
Localization AFM improves spatial resolution by localizing peaks in AFM data and reconstructing images from these localized points. This technique enables researchers to achieve resolutions beyond the limits of traditional AFM imaging, approaching the scale of individual atoms or molecular features.
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