Many patients with acute pancreatitis experience recurrent episodes, which are associated with a threefold higher incidence rate of developing chronic pancreatitis than a single episode.
The progression of acute pancreatitis is time-dependent, with the recurrence and progression rates to recurrent acute pancreatitis and chronic pancreatitis varying based on the follow-up duration and may be affected by the cause and severity of the first acute episode.
The primary outcomes were the incidence rates of recurrent acute and chronic pancreatitis following the initial episode of acute pancreatitis and the incidence rate of chronic pancreatitis after recurrent episodes of acute pancreatitis. The progression rate to chronic pancreatitis in adults was threefold higher after recurrent acute pancreatitis episodes than after the first acute pancreatitis episode .The overall progression rate into chronic pancreatitis was 8% after the first acute pancreatitis episode and 24% after recurrent episodes of acute pancreatitis. Progression to chronic pancreatitis among adults was highest among those with alcohol-induced disease, followed by idiopathic and biliary pancreatitis.
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