Folate fortification of staple foods has long been practiced in many countries.
By Dr. Liji Thomas, MDReviewed by Lily Ramsey, LLMAug 6 2024 Folate fortification of staple foods has long been practiced in many countries, including the USA. However, little is known about its requirement for health at later phases of life. A recent study in Life Science Alliance explored this question in elderly mice.
Folate is required to divide cells actively during fetal life. Folate antagonists are, therefore, useful in suppressing abnormal cell proliferation in cancer chemotherapy, rheumatoid arthritis, and psoriasis. Longevity is associated with lower methylation levels and by restricting methionine levels. This pattern has been observed at the transcriptional level as well. The current study examined changes in healthspan in aged mice with altered dietary folate intake.
This is the first direct evidence in favor of using drugs that limit 1C metabolism to increase the lifespan in invertebrates.Using historical data, the researchers showed increased lifespan in mice on low-dose MTX in five of eight experiments without adverse effects on health. This led to the present study where folate limitation in late life was tested in mice for its impact on healthspan.
Males in the F/C- group greyed less than in the other group, possibly indicating an improved healthspan. The folate restriction resulted in a lower anabolic rate, with reduced anabolic metabolites and limited transcripts expressing protein-encoding genes.
Cancer Cell Cell Proliferation Chemotherapy Colorectal Colorectal Cancer Diet Glycine Life Science Metabolism Metabolites Methionine Proliferation Psoriasis Rheumatoid Arthritis Serine Spina Bifida Yeast
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