Reducing COVID-19 burden: could Bacille Calmette-Guérin (BCG) vaccines confer protection? NEJM covid COVID19 SARSCoV2 bcg BCG vaccine bcgvaccine protection
By Pooja Toshniwal PahariaMay 1 2023Reviewed by Lily Ramsey, LLM In a recent study in The New England Journal of Medicine, researchers performed a randomized controlled trial to investigate whether Bacille Calmette-Guérin vaccines could lower coronavirus disease 2019 burden among healthcare workers.
About the study In the present international phase 3 RCT, researchers evaluated BCG Vaccination to Reduce the Impact of COVID-19 on Healthcare Workers effects. The complications included pneumonia, hospitalization, critical care unit admission, mechanical ventilation, oxygen supplementation, and death. The primary and secondary outcomes were evaluated after six months of randomization.
The team excluded individuals with prior SARS-CoV-2-positive test reports; individuals contraindicated for BCG vaccination; individuals who were administered BCG vaccines in the previous year; individuals who received live-attenuated vaccines in the previous month; individuals who received any COVID-19 vaccines; and individuals who participated in any other trial on COVID-19 prevention.
Severe SARS-CoV-2 infection occurred among 75 vaccinees and 61 placebo recipients, with risk estimates of 7.60% among BCG vaccinees and 6.50% among placebo recipients .
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