The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people.
University of BarcelonaJul 10 2024 The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidemia, a common condition in diabetics. Now, however, it could help address this serious liver disease , which still has no specific treatment.
Drug repurposing: a new life for medicines Metabolic dysfunction-associated steatotic liver disease is a condition formerly known as non-alcoholic fatty liver disease. It is a multisystem disorder, with a very heterogeneous origin and a diverse course that can degenerate into cirrhosis, liver cancer or liver failure. It usually has no clear symptomatology and the early stages can last for decades.
The common pathological manifestation of MASLD is hepatic steatosis . Although it can be reversed with lifestyle changes, diet and exercise, in practice it is difficult to control and there are no specific drugs to treat it. The repositioning of drugs with a good safety profile for clinical use in other pathologies is an optimal approach to finding new treatments."
In an experimental model of SLD in female rats, pemafibrate prevents the development of hepatic steatosis, increases fatty acid catabolism and cholesterol clearance in the liver, and shows a good safety profile. As the preclinical study was conducted in female rats, the findings could also help to identify sex differences in the physiology of chronic diseases and thus reduce gender bias in biomedical research.
Lipids Liver Liver Disease Biomedicine Cholesterol Drugs Fatty Liver Food Laboratory Metabolic Disorders Nutrition Pathology Physiology Receptor Research Steatosis
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