A MedUni Vienna study has investigated gender-specific differences in the diagnosis of systolic heart failure in patients with type 2 diabetes.
Medical University of ViennaAug 5 2024 The results, recently published in the specialist journal "Cardiovascular Diabetology", show that the current methods are less reliable in women than in men. In view of the prevalence of the heart disease , particularly in women with type 2 diabetes , it is recommended that gender aspects be taken into account in existing guidelines to ensure the best possible care for patients.
As part of the study, the scientific team led by gender medicine specialist Alexandra Kautzky-Willer from the Division of Endocrinology and Metabolism , in collaboration with Martin Hülsmann and other colleagues from the Division of Cardiology , analysed data from 2083 patients with type 2 diabetes collected over a period of five years. Common methods and parameters for the diagnosis of systolic heart failure in T2D were analysed, with a particular focus on gender-specific differences.
T2D patients are up to four times more likely to have heart failure than people without T2D, with women more than twice as likely to be affected as men. Despite the pathophysiological differences between men and women, which lead to different predispositions and courses of the disease, there are currently no gender-specific recommendations for the diagnosis of heart failure in patients with T2D.
Early diagnosis is crucial for prognosis As the current study shows, this standardized approach does not meet the specific needs of female and male T2D patients: while higher NYHA grades are associated with higher NT-proBNP values, more frequent heart failure diagnoses and a higher risk of death in men, this correlation was not found in women. In contrast, the significance of NT-proBNP for heart failure was significantly higher in both sexes, but especially in women, than the clinical symptoms.
Our results suggest that reduced performance may not be suitable for screening heart failure in women with T2D." "NT-proBNP values, on the other hand, can be very sensitive and early markers of heart failure, especially in women. Diagnosing the heart disease as early as possible and adapting the treatment with new, very effective drugs is essential for the prognosis of patients with T2D," adds study leader Alexandra Kautzky-Willer.
Diagnostic Heart Heart Failure Type 2 Diabetes Endocrinology Heart Disease Medicine Metabolism
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