Study highlights the association between sleep duration and proteomic fingerprints, finding that very short sleep is linked to proteins involved in inflammation and cell death that increase the risk of diabetes mellitus (DM) but not coronary heart disease (CHD).
By Dr. Liji Thomas, MDMay 1 2024Reviewed by Benedette Cuffari, M.Sc. Diabetes mellitus is a lifestyle disorder that is associated with various adverse health outcomes, including cardiovascular disease and unhealthy sleep patterns. Epidemiologic studies and other research emphasize the association between both long and short sleep duration, CVD, and metabolic disease .
About the study The current study examines proteins that may be implicated in different sleep durations to generate proteomic scores that can predict the sleep duration category for each score and identify associations between these scores with incident DM and CHD . Comparatively, Q1 participants had the fewest drinkers, highest insomnia scores, and highest low-density lipoprotein levels.
When these scores were included in the model parameters, there was no longer any significant correlation between Q1 and iDM. Thus, PSQ1 accounted for 30-50% of the association from years 11 to 27. If sex stratification is used in future studies, the longest sleep duration might reveal an equal or greater association with CHD risk. This trend has been observed in a larger sample from the same cohort, wherein men who slept more than nine hours a night had a 33% higher CHD risk than was not observed in women with similar sleep patterns.
Heart Heart Disease Sleep Cardiovascular Disease Cell Cell Death Coronary Heart Disease Diabetes Mellitus Inflammation Insomnia Medicine Metabolic Disease Protein Research
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