Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model biorxivpreprint univ_paris_cite univamu covid coronavirus COVID19
By Neha MathurFeb 17 2023Reviewed by Danielle Ellis, B.Sc. *Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
The exceptional immune-evasion potential of Omicron BA.5 subvariants, especially BQ.1.1, the currently circulating variant in Europe, has also limited the mAb-based therapeutic options to treat patients suffering from severe coronavirus disease 2019 . About the study In the present study, researchers used three female cynomolgus macaques , tagged M1 to M3, aged 14-15 years, for in vivo experiments with Sotrovimab. They intravenously administered 10 milligrams of Sotrovimab per kilogram weight of the test animal 96 hours before the SARS-CoV-2 challenge.
The team regularly collected tracheal fluids and blood samples after the challenge, while Broncho alveolar lavages at three and 10 d.p.c. They followed NHPs for behavior assessment and clinical scores during the infection duration, including their blood cell counts and hemoglobin.
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