Researchers of the University of Barcelona and the August Pi y Sunyer Biomedical Research Institute (IDIBAPS) have shown that the IGFBP3 protein plays a relevant role in human lung development.
University of BarcelonaNov 1 2024 Research ers of the University of Barcelona and the August Pi y Sunyer Biomedical Research Institute have shown that the IGFBP3 protein plays a relevant role in human lung development. The results of the study, which used organoids derived from embryonic lungs, open up new perspectives on how this organ develops and lay the foundations for future strategies for both prevention and treatment of lung diseases, especially in neonatal respiratory pathologies.
As the lung develops, IGFBP3 expression must be reduced for cell differentiation to take place, a process necessary for proper lung tissue formation. "As embryogenesis progresses, this protein needs to be silenced, which tells us that it is key to maintain lung stem cells", the researcher adds. Simulating lung development using organoids The study has been carried out thanks to the generation and establishment of organoids derived from embryonic lungs between the 8th and 12th week of human development, which replicate this organ at the molecular and cellular level. "In our study, we observed that IGFBP3 gene expression was associated with embryonic lung progenitor cells. Therefore, we needed an in vitro model that could reproduce this expression", says the researcher.
Cell Embryogenesis Gene Gene Expression Inflammation Lung Cancer Lungs Medicine Molecule Organoids Pluripotency Protein Research Respiratory Stem Cells
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