Research uncovers alternate mechanism for producing key protein in metastatic prostatecancer danafarber naturecancer
, Dana-Farber Cancer Institute scientists shed new light on the mechanism that raises and lowers PSMA expression in prostate cancer cells. The findings may help physicians select PSMA-targeting therapies for specific patients.in response to the hormone androgen—controls the production of PSMA in prostate cancer cells. In thestudy, researchers led by Dana-Farber's Himisha Beltran, MD, and Martin Bakht, Ph.D.
Their search revealed that the HOXB13 protein as a key regulator of PSMA: when castration-resistant prostate cancers go without the AR, HOXB13 can control PSMA on its own. This and the discovery of an"epigenetic" mechanism for suppressing PSMA demonstrate that the system of PSMA control is more complex than once thought and that prostate cancer has multiple subtypes that may be optimally treated by specific targeted therapies.
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