Preeclampsia is a life-threatening pregnancy complication marked by persistent high blood pressure that is even more serious when it occurs early in the first trimester.
American Chemical SocietyOct 14 2024 The exact cause of early-onset preeclampsia is unknown, and it is difficult to predict, prevent and diagnose. Now, in ACS' Journal of Proteome Research, researchers report on six proteins that could be used as targets to diagnose and treat the condition.
Preeclampsia's key symptom is high maternal blood pressure, and serious cases can lead to maternal organ failure, low infant birth weight, or maternal or fetal death. Preeclampsia before 34 weeks of pregnancy has a higher risk of severe outcomes, especially for the fetus. But it's difficult for health care providers to detect this condition before harmful symptoms appear, because little is known about what causes it.
The researchers collected placenta tissue from 30 pregnant people, half with early-onset preeclampsia and half with healthy pregnancies. Li and colleagues used mass spectrometry to screen molecular fragments in each sample, followed by a software program to match the fragments to their associated proteins. This process pinpointed 59 proteins that were present in different amounts for preeclamptic placenta tissue samples versus healthy placenta tissue samples.
Related Stories Altogether, the results suggest that cardiovascular complications or the estrogen cycle could be linked to the development of early-onset preeclampsia. The team says that more research is needed, but identifying these six proteins serves as a promising first step toward improved detection and treatment of this life-threatening condition.Journal reference:Zhou, J., et al. .
Blood Blood Pressure Estrogen Health Care High Blood Pressure Mass Spectrometry Placenta Pregnancy Protein Proteome Research Spectrometry
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Lupus Research Alliance announces 2024 Diversity in Lupus Research Award recipientsThe Lupus Research Alliance (LRA) is pleased to announce the recipients of the 2024 Career Development and Postdoctoral Awards to Promote Diversity in Lupus Research.
Read more »
Study finds defective sperm doubles the risk of preeclampsiaFor the first time, researchers have linked specific frequent defects in sperm to risk of pregnancy complications and negative impacts on the health of the baby.
Read more »
AI-powered research to advance understanding of radiation exposure risksKeck Graduate Institute (KGI), a member of The Claremont Colleges, has been awarded a significant grant from the Department of Energy to investigate the effects of low-dose radiation on human beings.
Read more »
New research strengthens the case for a zoonotic origin of COVID-19A new international collaborative study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC).
Read more »
New cancer research breakthrough has the potential to save livesUMass Chan researchers can shrink tumors in mice; hope to do this to humans and save patients from pancreatic cancer
Read more »
New cancer research breakthrough has the potential to save livesUMass Chan researchers can shrink tumors in mice; hope to do this to humans and save patients from pancreatic cancer
Read more »