Researchers describe a new way to visualize force-sensing neurons neurocellpress
, was led by Dr. Kara Marshall, assistant professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, with Dr. Ardem Patapoutian, Nobel Laureate and professor at Scripps Research Institute.
"However, one of the challenges in understanding mechanosensation is our inability to specifically identify mechanosensory neurons. Unfortunately, antibodies against PIEZO2 or a PIEZO2-GFP knock-in mouse have had limited efficacy for in vivo localization of PIEZO2—a technical hurdle that the scientists in the field have struggled with for years and one that has slowed down further progress.
Based on these and other experiments, the authors concluded that although FM 1-43 is non-specific in vitro, it specifically labels PIEZO2-dependent mechanosensory neurons in vivo. The mechanisms underlying these differences in FM 1-43 labeling remain to be explored.
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