Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability.
European Molecular Biology LaboratoryAug 12 2024 Researchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a critical type of protein modification process called ubiquitination. Ubiquitination plays an integral role in diverse cellular functions, and its dysregulation contributes to many human diseases, including neurodegeneration and cancer.
The diversity of cellular functions of ubiquitination is reflected in the existence of over 600 human E3 ligase genes, representing ~3% of the human genome. Mapping the human E3 target protein landscape can help us understand their function and eventually target them for therapeutics. To solve this problem, the Bhogaraju Group, which investigates ubiquitination pathways in various physiological contexts, developed a simple, cost-effective method, named Ub-POD, to quickly and easily label the targets of a given E3 ligase enzyme directly in human cells.
Cancer DNA DNA Damage Ligase Molecular Biology Neurodegeneration Ubiquitin Ubiquitin Ligase
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