A multi-institutional group of researchers led by the Hubrecht Institute and Roche's Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion.
Hubrecht InstituteOct 18 2024 A multi-institutional group of researchers led by the Hubrecht Institute and Roche's Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion. In response to incoming food, these hormones are secreted by rare hormone producing cells in the gut and play key roles in managing digestion and appetite.
Medications that mimic gut hormones, most famously GLP-1, are very promising for the treatment of multiple metabolic diseases. Directly manipulating EECs to adjust hormone secretion could open up new therapeutic options. However, it has been challenging to understand how gut hormone release can be influenced effectively.
In the past, the Hubrecht researchers developed a way to increase the number of EECs in organoids of the intestine. Considering that EECs have different sensors and hormone profiles in different regions of the gut, studying these rare cells requires that the researchers make EEC enriched organoids of all these different regions.In the current study, the team managed to enrich EECs in organoids of other parts of the digestive system, including the stomach.
Cell Digestion Endocrine Food Hormone Nutrients Oncology Organoids Ph Receptor Research Stomach Vitamins
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