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But varying arrays of hydrogen atoms also exist within us, and Maloney wanted to see if those isotopes could shed light on mysteries within our bodies. Drawing inspiration from her father's work as a dermatologist, she specifically wanted to learn what hydrogen isotopes might reveal about cancer.."I wondered how the metabolism of those cells might be different from the cells growing next to them.
Yeast and mouse cells typically generate energy via cellular respiration, taking in oxygen and releasing carbon dioxide. But when oxygen isn't freely available, most cells can at least temporarily turn to fermentation to break down sugars into energy instead. . Knowing this, scientists have long sought methods for monitoring metabolic anomalies that could herald cancer cells in patients.
Based on the activity of other enzymes in a cell, NADPH may cobble together various ratios of hydrogen and deuterium atoms.
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