For people with autism, constipation, diarrhea, and abdominal pain often go along with the social struggles and repetitive behaviors that define the condition.
May 13 2024University of Utah Health This has prompted many to wonder whether gastrointestinal problems arise due to autism's behavioral or sensory features, or whether they might instead contribute to them.
"I think that this is a really important step therapeutically, because now we can start to assemble a therapy with organisms that we know to be safe," says June Round, Ph.D., a microbiologist at U of U Health, who led the research. "It's not like the mice are under so much pain that they're not doing anything," Brown says. "So maybe it is something specific to sociability and not just that the mice feel poorly."
Related StoriesWhen he induced colitis in those animals, mice carrying microbes from individuals with autism had more intestinal damage and lost more weight than mice whose microbes came from neurotypical individuals. It seemed that the mix of microbes collected from neurotypical individuals had a protective effect.
"We were able to pick out individual microbes that we thought might be playing important roles in resisting severe colitis," explains Brown, who is now a fellow at the National Institutes of Health Clinical Center.
Abdominal Pain Bacteria Constipation Diarrhea Microbiome Pain Ph Research
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