Researchers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.
May 28 2024Julius-Maximilians-Universität Würzburg, JMU Research ers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.
A team of researchers at the University of Würzburg has now discovered for the first time exactly how the XPD protein is able to detect and verify the presence of a DNA damage. The team was led by the biochemist Caroline Kisker, Chair of Structural Biology at the Rudolf Virchow Centre in Würzburg, in collaboration with the chemist Claudia Höbartner from the Department of Organic Chemistry.
Interstrand crosslinking causes DNA to be incorrectly copied and read during cell division. This leads to genetic damage that can trigger cancer." In their study, the scientists used cryo-electron microscopy to analyse how XPD unwinds the double helix of DNA to reveal the defective sites of interstrand cross-linking, and created a model of how the damage is detected and removed.
DNA Research DNA Damage Nucleotide Protein
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