RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies.
University of MarylandFeb 4 2025 RNA -based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA therapies. But while health care providers can now successfully develop drugs that use ds RNA to accurately target and silence disease-causing genes, a major challenge remains: getting these potentially life-saving RNA molecules into cells efficiently.
"Interestingly, you can find proteins similar to SID-1 in other animals including humans," Jose noted. "Understanding SID-1 and its role has significant implications for human medicine. If we can learn how this protein controls RNA transfer between cells, we could potentially develop better targeted treatments for human diseases and perhaps even control the inheritance of certain disease states.
Related StoriesJose believes the team's findings provide valuable insights into how animals regulate their own genes and maintain stable gene expression across generations. Studying these mechanisms could potentially pave the way for innovative future treatments for heritable diseases in humans.
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