Researchers discover key role of DNAmethylation in Alzheimer's disease mountsinainyc
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
that sheds new light on the role of DNA methylation in Alzheimer's disease . The study found that DNA methylation has a profound impact on gene and protein co-expression networks associated with AD and could lead to the discovery of new neuropathological processes and molecular mechanisms for developing novel treatments for the disease.
The study was conducted using a novel analytical approach to quantify the impact of DNA methylation on gene and protein expression and a large cohort of post-mortem control, mild cognitive impaired , and AD brains from the Mount Sinai Brain Bank. The researchers profiled genome-wide methylomic variations in the, a region of the brain involved in a variety of functions including memory processing, and investigated the influence of these changes on mRNA and protein co-expression networks.
"Our study represents the first comprehensive effort to integrate high-throughput profiling of multi-omics in Alzheimer's disease," said senior author, Bin Zhang, Ph.D., Willard T.C. Johnson Research Professor of Neurogenetics and Director of the Mount Sinai Center for Transformative Disease Modeling.
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