A team of researchers from Penn State College of Medicine found a new target for treating diseases associated with human T-cell leukemia virus type 1 (HTLV-1).
Penn StateJul 22 2024 A team of researchers from Penn State College of Medicine found a new target for treating diseases associated with human T-cell leukemia virus type 1 . They determined that blocking a class of enzymes called kinases, which regulates cellular functions, leads to cell death caused by the degradation of Tax, a protein essential for viral gene expression , viral transmission and survival of cells infected by HTLV-1. The team published the findings in Nature Communications.
Edward Harhaj, professor of microbiology and immunology at Penn State College of Medicine and senior author of the study The study showed that KDR's role in the survival of HTLV-1-infected cells is connected to the viral protein called Tax. Tax is crucial for viral gene expression, viral transmission and the development of cancer. Suppression of KDR leads to the degradation of Tax and disrupts cancer-causing signaling pathways, leading to cell death. Cells that didn't express Tax weren't sensitive to KDR inhibition and didn't die.
Virus Blood Cancer Cell Cell Death DNA Gene Gene Expression Genetic Immunology Kinase Lymphoma Medicine Microbiology Multiple Sclerosis Protein Research Retrovirus Sclerosis T-Cell Tyrosine
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