Superbugs, bacteria that are immune to multiple antibiotics, pose a great challenge to modern medicine. Researchers from the B CUBE - Center for Molecular Bioengineering at TUD Dresden University of Technology and Institut Pasteur in Paris identified a weakness in the bacterial machinery that drives antibiotic resistance adaptation.
Technische Universität DresdenDec 17 2024 Their findings, published in the journal Science Advances, could pave the way to boosting the effectiveness of existing antibiotics.
A genetic toolbox in action "Our work focuses on the integron system, a genetic toolbox that bacteria use to adapt to their environment by exchanging genes, including those for antibiotic resistance," says Prof. Didier Mazel, research group leader at Institut Pasteur in Paris, whose group worked together with the Schlierf team.
Related StoriesThe Schlierf group used a cutting-edge microscopy setup to study how strongly a recombinase protein binds the different DNA hairpin sequences. They found that the complexes with the strongest binding between the protein and the DNA are also the ones that are the most efficient at gaining resistance genes.
Antibiotic Resistance Bacteria Bioengineering Chronic DNA Drugs Genes Genetic Infectious Diseases Medicine Microscopy Penicillin Protein Research Technology
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