itemprop=description content=Researchers have delved into the intricate heterogeneity of glioblastoma, a notoriously aggressive brain tumor, using advanced single-cell RNA sequencing and innovative zebrafish avatars. Their findings spotlighted the LGALS1 gene's role in immunosuppression and suggested potential therapeutic avenues for personalized GBM treatment.
By Neha MathurOct 8 2023Reviewed by Sophia Coveney In a recent article published in EMBO Molecular Medicine, researchers investigated cellular, molecular, and spatiotemporal heterogeneity of glioblastoma , a malignant and highly aggressive primary brain tumor.
In contrast to other macrophages, GAMs are highly plastic immune cells exhibiting immunosuppressive properties that promote tumor progression instead of preventing tumor formation. Then, they collected cells in various conditions, labeled them using the MULTI-seq methodology, and pooled them for scRNA-seq.
Related StoriesIn addition, an image analysis pipeline processed in vivo recordings, which helped identify distinct spatiotemporal behavioral patterns of GSCCs and GAMs. The advanced image processing pipeline captured the complex spatiotemporal interactions between GSCCs and GAMs. They uncovered differential tumor cell invasion and infiltration of reactive GAMs across different in vivo models. In addition, they revealed how tumor cell invasion and infiltration of reactive GAMs varied across patients.
Differential gene expression analysis and immunohistochemistry on GBM tumor samples and knock-out experiments in zebrafish identified the LGALS1 gene as a primary regulator of immunosuppression. Studies have implicated the LGALS1 gene encoding galectin-1 protein in modulating cell-cell and extracellular cell-matrix interactions.
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