How does our body control blood sugar so precisely? An international research team led by scientists from the Paul Langerhans Institute Dresden (PLID) of the German Center for Diabetes Research brought us a step closer to the answer.
Deutsches Zentrum fuer Diabetes forschung DZDJul 17 2024 How does our body control blood sugar so precisely? An international research team led by scientists from the Paul Langerhans Institute Dresden of the German Center for Diabetes Research brought us a step closer to the answer. They found a special group of "first responder" cells in the pancreas that are crucial for triggering blood sugar response. Their findings were published in the journal Science Advances.
Not all beta cells are equal Looking at the pancreas, we wondered if all beta cells are actually equally sensitive to sugar. Previous studies suggested some might be more sensitive than others." To understand the work of the pancreas, the Ninov team turned to zebrafish. This small tropical fish has a pancreas that works similarly to a human one. At the same time, it offers a huge advantage.
Hidden hierarchy in the pancreas The team wanted to test if first responders are necessary for the follower cells to respond to glucose. Using transparent fish, the Ninov group took advantage of optogenetics, a modern light-based technology that allows to turn single cells on or off with a beam of light. Turning off the first responder cells lowered the response to the blood sugar of the follower cells.
Blood Sugar Optogenetics Cell Diabetes Fish Glucose In Vivo Insulin Pancreas Research
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