Researchers found a molecular mechanism, shared in cancer and pregnancy, that suppresses the immune system. Block this mechanism, called B7-H4, and the immune system revs up to slow cancer's growth.
By understanding how the immune system is suppressed in pregnancy, researchers pinpointed a key mechanism that stops the immune system from blocking cancerResearchers found a molecular mechanism, shared in cancer and pregnancy, that suppresses the immune system. Block this mechanism, called B7-H4, and the immune system revs up to slow cancer's growth.
It's a good thing in pregnancy -- it allows the baby to grow. But in cancer, it means the tumor grows unchecked and treatments meant to stimulate an immune response are not effective. Further, while the male hormone androgen has previously been linked to immune suppression in prostate cancer, this is the first time the female sex hormone progesterone has been shown to impact immune response in cancer.
Immune System Breast Cancer Diseases And Conditions Public Health Bioethics Government Regulation
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