Alzheimer's is a debilitating neurodegenerative and neuroinflammatory disease that is difficult to treat. Most existing therapies target the buildup of amyloid beta (Aβ) plaques in the brain, which requires early intervention and intravenous therapy.
A team of researchers from Brigham and Women's Hospital, a founding member of the Mass General Brigham health care system, tested whether a therapy being tested in multiple sclerosis patients that dampens immune cell inflammation in thecould have a positive effect in Alzheimer's mouse models. They found that a nasal immunotherapy—anti-CD3—reduced inflammation and improved cognition independent of Aβ plaques.
In this study, mice were treated three times a week with an intranasal anti-CD3 for five months. The therapy effectively limited the activation of microglia—
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