Researchers find that SARS-CoV-2 directly infects hepatocytes that cause hyperglycemia PNASNews COVID19 SARSCoV2 covid hepatocytes hyperglycemia
By Neha MathurMay 18 2023Reviewed by Lily Ramsey, LLM In a recent study published in PNAS, researchers performed a retrospective cohort study among patients hospitalized on suspicion of coronavirus disease 2019 between March and August 2020 in Brazil to investigate whether severe acute respiratory syndrome coronavirus 2 caused hyperglycemia.
In addition, studies should explore the mechanism of infection of hepatocytes by SARS-CoV-2 and whether such an infection is productive. The team applied the ex vivo, and in vitro experimental strategies to show how SARS-CoV-2 infects hepatocytes. Furthermore, the team collected postmortem liver biopsies to determine whether SARS-CoV-2 and its transporters were present in hepatocytes. Additionally, they studied the mechanistic bases of SARS-CoV-2 entrance and its gluconeogenic effect in human hepatocytes.
Intriguingly, COVID-19-positive patients exhibited a higher incidence of hyperglycemic episodes over their hospital stay, regardless of their diabetes status. High blood glucose and serum protein levels of COVID-19-positive patients than COVID-19-negative patients indicated that these patients secreted insulin at physiological levels in response to hyperglycemia, at least by the time of admission.
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