Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions have gained new insights into the molecular changes leading to Rett syndrome, a severe neurological disorder caused by mutations in the MeCP2 gene encoding methyl-CpG binding protein...
Baylor College of Medicine Dec 16 2024 Research ers at Baylor College of Medicine , Jan and Dan Duncan Neurological Research Institute at Texas Children 's Hospital and collaborating institutions have gained new insights into the molecular changes leading to Rett syndrome, a severe neurological disorder caused by mutations in the MeCP2 gene encoding methyl-CpG binding protein 2 .
During the development of an organism, many genes are expressed and repressed – many 'harmonies' are played simultaneously creating a complex composition. It can be challenging to distinguish the harmonies emerging from the lack of MeCP2 from the others. A key finding from this study is that neuronal circuit-level deficits occurred after gene expression dysregulation, suggesting Mecp2 deletion leads to bidirectional dysregulation of gene expression first and that in turn contributes to reduced neuronal function.
Syndrome Brain Children Cpg Gene Gene Expression Genes Hospital Medicine Neuron Neurons Protein Research
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