Researchers identify a novel RSV variant associated with prolonged infection Respiratory Syncytial Virus RSV Infectious Disease Pathogen Respiratory JIDJournal epfl EmoryUniversity PittTweet VanderbiltU
By Suchandrima BhowmikNov 20 2022Reviewed by Benedette Cuffari, M.Sc. A new The Journal of Infectious Diseases study examines pathogen or host genetic risk factors for RSV infection and whether certain viral variants are associated with prolonged infection.
All children between the age of two to three years are infected by RSV at least once. RSV mainly infects the lower and upper respiratory tract epithelium; however, it has also been found in non-airway sources. Although RSV typically causes acute respiratory infection, it can also lead to persistent or prolonged illness in some individuals.
About the study The current study involved healthy-term infants who suffered from prolonged RSV infection. A viral genome-wide association study was performed using RSV whole-genome sequencing to understand the relationship between prolonged RSV infection in infants and viral genotypes. RSV infection had little to no impact on the genotypes of the infants. Moreover, prolonged infection was caused by viruses from different phylogenetic clades compared to a single specific clade. Similar RSV sequences were observed for initial and subsequent viral detection, thus suggesting that these were prolonged infections.
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