Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time.
Broad Institute of MIT and HarvardSep 19 2024 Gram-negative bacteria such as Enterobacteriaceae are a common cause of these infections and have few treatment options. Fecal microbiota transplants have shown promise to curb some of these infections, but their composition varies between batches and they aren't always successful.
"Despite two decades of microbiome research, we are just beginning to understand how to define health-promoting features of the gut microbiome," said Marie-Madlen Pust, a computational postdoctoral researcher at Broad and co-first author on the paper. Kenya Honda of the Keio University School of Medicine is co-senior author of the study. Munehiro Furuichi, Takaaki Kawaguchi, and Keiko Yasuma-Mitobe, all researchers at Keio University, are co-first authors. In this work, the Honda lab used specialized culture techniques and animal models to analyze bacterial infections, while the Xavier lab developed software to analyze unknown microbial metabolites.
Xavier's team wanted to study samples from patients with and without gut inflammation. In partnership with the Broad's Metabolomics Platform, led by senior director and study co-author Clary Clish, they analyzed samples from pediatric patients with ulcerative colitis, looking for the presence of alternate gluconate pathway genes of gut microbes and fecal gluconate levels.
Bacteria Chronic E. Coli Genes Inflammation Inflammatory Bowel Disease Medicine Metabolites Microbiome Research Therapeutics Transplant Ulcerative Colitis
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