Even years after they have recovered, a person who once struggled with alcohol or opioid addiction can relapse--and that relapse is more likely to occur during particularly stressful times. Now, scientists have identified an area of the brain that plays a key role in stress-induced oxycodone relapse.
Their findings explain why the drug suvorexant, which they previously found to reduce alcohol and oxycodone relapse when administered orally, works so well.
Recently, Martin-Fardon's team showed that when alcohol-dependent rats were given the drug suvorexant , they drank less alcohol and were less likely to experience stress-induced relapse. Similar experiments suggested that it also could prevent opioid relapse elicited by drug-associated cues. Then, the researchers developed a system to expose only one small area of the rats' brains, known as the posterior paraventricular nucleus of the thalamus , to suvorexant, rather than giving the drug orally which exposes the entire brain to the drug. The pPVT has been previously shown to play a role in stress, eating and drinking.
"Relapse is a huge problem for people with opioid use disorder and alcohol use disorder and this gets us one step closer to identifying the proper types of treatment to reduce the risk of relapse," says Illenberger. Jessica M Illenberger, Francisco J Flores-Ramirez, Glenn Pascasio, Marissa Franco, Brandon Mendonsa, Rémi Martin-Fardon.
Patient Education And Counseling Workplace Health Pharmacology Opium Alcoholism Addiction Stress
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