Researchers identify gene associated with kidney disease

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Researchers identify gene associated with kidney disease
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Chronic kidney disease is a public health burden impacting more than 37 million people worldwide, including nearly one million Americans. It is characterized by the accumulation of toxins, which further damages the kidney, yet the mechanisms responsible for this phenomenon needs to be better understood.

Researchers from Boston University Chobanian & Avedisian School of Medicine have discovered a novel protective gene that may unravel the mechanism of how"Kidney damage from any cause is associated with the accumulation of a host of toxins. The novelty of our finding is the contribution of the TMIGD1 gene to

, and secondly, we have deciphered how toxins contribute to kidney failure, thereby worsening renal function," explains corresponding author Vipul Chitalia, MD, Ph.D., associate professor of medicine at the school., the researchers showed that when toxins inactivated the TMIGD1 gene, the models were more susceptible to kidney injury. This study explains how TMIGD1 functions to protect kidneys and describes a new mechanism by which accumulated toxins inflict kidney damage.

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