Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.
Chiba UniversityJul 11 2024
Overproduction of Group 2 innate lymphoid cells or ILC2s-;a type of white blood cells-;can sometimes exacerbate conditions such as bronchial asthma, chronic rhinosinusitis, atopic dermatitis, and organ fibrosis through an exaggerated immune response. Although there are immunomodulatory drugs that can suppress Type 2 helper T cells, drugs capable of suppressing ILC2s are currently lacking.
"Since allergic diseases can flare up after discontinuation of current Type 2 cytokine inhibitor drugs, we undertook this study to elucidate and control the upstream regulation of Type 2 cytokine production, i.e., the in vivo Th2 cell differentiation and ILC2 development mechanisms, which we believe are important issues in the control of allergic disease," adds Dr. Iwata, explaining the specifics of their study further.
Related StoriesUsing genetically modified G3SE-deficient mice and with methods such as single-cell RNA sequencing and flow cytometry, they found that the GATA3 induction mechanism is crucial during a late stage in ILC2 production. Since the mice lack G3SE, GATA3 levels did not spike sufficiently during this stage in precursor maturation, and as a result, the researchers found the G3SE-deficient mice had significantly low levels of ILC2s.
Asthma Atopic Dermatitis Blood Chronic Cytokine Dermatitis Drugs Fibrosis Gene Hospital Immune Response Immunology Immunomodulatory In Vivo Protein Research Rhinosinusitis
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Novel mechanism of ILC2 immune cell development may be involved in exacerbating allergic diseasesOverproduction of Group 2 innate lymphoid cells or ILC2s—a type of white blood cell—can sometimes exacerbate conditions such as bronchial asthma, chronic rhinosinusitis, atopic dermatitis, and organ fibrosis through an exaggerated immune response.
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