A new University of Maryland-led discovery could spur the development of new and improved treatments for Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder with no known cure that causes accelerated aging in children.
University of MarylandOct 18 2024 A new University of Maryland-led discovery could spur the development of new and improved treatments for Hutchinson-Gilford progeria syndrome , a rare genetic disorder with no known cure that causes accelerated aging in children.
"This could pave the way for new treatments targeting cardiovascular complications in HGPS, which are currently a major cause of mortality in the affected children," Vakili said. More specifically, the researchers wanted to understand the signals sent by endothelial cells that ultimately lead to HGPS-related cardiovascular disease. For the first time, the team discovered that Angiopoietin-2 -;a protein that regulates the formation of new blood vessels and the flow of substances through blood vessel walls-;is significantly impaired in individuals with progeria, affecting the overall function of their endothelial cells.
Current treatments for HGPS can help reduce the risk of fatal complications like heart attack and stroke, but they do not target the underlying disease. Cao explained that their research is unlikely to offer a definitive progeria cure, but it could buy patients more time by improving their health in other ways.
Angiogenesis Blood Blood Vessels Cardiovascular Disease Cell Children Endothelial Cell Genetic Genetic Disorder Heart Heart Failure Hutchinson-Gilford Progeria Life Expectancy Ph Progeria Protein Receptor Research Stress Stroke Syndrome Vascular Vasculature
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