Researchers elucidated the shared immune tolerance mechanisms in cancer and pregnancy, focusing on the role of an immune checkpoint protein as an onco-fetal immune tolerance checkpoint.
By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Jul 11 2024 In a recent study published in Cell , a group of researchers elucidated the shared immune tolerance mechanisms in cancer and pregnancy, focusing on the role of progestogen-induced B7 Homolog 4 as an onco-fetal immune tolerance checkpoint .
About the study In the animal studies, a spontaneous tumor model was induced using Medroxyprogesterone Acetate and 7,12-Dimethylbenzanthracene Mice were randomized into treatment groups and monitored for tumor-free and overall survival. B7-H4 expression on mouse endometrial epithelial cells was examined by administering RU486 to WT mice and harvesting the uteri for cell isolation.
Related StoriesThe analysis confirmed previously reported key genes expressed in tumor and trophoblast cells. For instance, high Fibrinogen-like protein 1 expression was found in tumor cells, and high HLA-G expression in trophoblast cells in the placenta. Interestingly, B7-H4 V-Set Domain Containing T Cell Activation Inhibitor 1 was ranked as the top gene highly expressed in tumor cells in the TME and trophoblast cells in the placenta.
At the maternal-fetal interface, B7-H4 was mainly expressed by trophoblast cells. Human trophoblast cells consist of anatomically and functionally different subsets, including extravillous trophoblast cells , villous cytotrophoblast cells , and syncytiotrophoblast . The expression of B7-H4 transcripts in trophoblast subsets from human first-trimester pregnancies, a critical stage for establishing maternal-fetal immune tolerance, was analyzed.
Immune System Pregnancy Antigen Cell Cell Line Human Leukocyte Antigen IHC Immunotherapy Leukocyte Ligand Medroxyprogesterone Acetate MPA PD-L1 Placenta Progestogen Protein Research RNA Tumor
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