Researchers issue a warning that GLP-1RAs may be dangerous for children

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Researchers issue a warning that GLP-1RAs may be dangerous for children
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A team of clinicians, exercise scientists, pharmaceutical scholars, ethicists, and behavioral experts at the University of California, Irvine, outlined their concerns that the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) to treat childhood obesity and type 2 diabetes may have unintended and adverse consequences for children's health.

,"said Cooper, associate director of the UCI Institute for Clinical and Translational Science and interim director of the UCI Institute for Precision Health."Unlike in adults, children and adolescents need energy and sufficient calories not only for physical activity, but for growth and development."

The team also pointed out the likelihood of abuse among patients with diagnosed eating disorders and children and adolescents involved in competitive sports like wrestling,"The benefit vs. cost relationship of long-term use in youth needs to be carefully studied,"said Jan D. Hirsch, one of the co-authors, dean of the School of Pharmacy and Pharmaceutical Sciences at UCI.

With the growing efficacy and popularity of these medications, drug manufacturers are quicky developing oral forms of the drugs, which researchers believe could limit oversight and cause cases of abuse. Anecdotal clinical experience suggests that there is already widespread knowledge in the pediatric population about the GLP-1RA effectiveness as satiety medications aiding weight loss, not helped by apparent widespread use documented in the popular media.

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