Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear.
May 29 2024Weill Cornell Medicine The results, published on May 29 in Developmental Cell , overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has a chance to become established.
"We wanted to determine how those two routes really start and how they progress, so we can better understand their heterogeneity as the cancer progresses," said co-senior author Dr. Maria Diaz-Meco, Homer T. Hirst Professor of Oncology in Pathology in the Department of Pathology and Laboratory Medicine at Weill Cornell Medicine and a member of the Meyer Cancer Center at Weill Cornell Medicine.
"We approached this project with the bottom-up and top-down theories, but we were surprised to find that both tumor types showed loss of intestinal stem cells after aPKC genes were inactivated," said Dr. Moscat, who is also a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.
Colorectal Colorectal Cancer Bottom-Up Cell Colon Genes Genetic Laboratory Medicine Oncology Pathology Protein Protein Expression Research Stem Cells Top-Down Tumor
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