UCLA Health researchers, in collaboration with researchers from the Republic of Ireland and Northern Ireland, have received $9.
University of California - Los Angeles Health SciencesAug 5 2024 5 million award from the National Institutes of Health with support from European funding agencies -; The Science Foundation Ireland and the Public Health Agency Health & Social Care -; to study the effects of polyphenols on cognitive health and the brain-gut microbiome system.
It's a multicenter, longitudinal, and translational intervention study designed so that we can look at the mechanisms and pathways involved in cognitive decline. We're looking at multiple markers such as cognitive functioning, brain structure and function, the microbiome and microbial polyphenol metabolites, inflammatory markers like interleukins, and Alzheimer's disease-specific plasma markers such as tau proteins ptau181 and ptau217.
"We're hoping to better understand the role of dietary polyphenols in slowing the development of cognitive decline and how this is all influenced by the brain and gut microbiome," Church said. "This will help us better understand the ameliorative properties of a polyphenol-rich diet and whether diet interventions and regimes to delay the onset and progression of cognitive decline.
In this interdisciplinary and multicenter study funded through the Tripartite US-Ireland Research & Development Partnership Program, researchers will investigate the impact of dietary polyphenol supplements on 300 older adults at-risk for Alzheimer's disease.
Microbiome Polyphenol Alzheimer's Disease Bile Bioinformatics Cognitive Function Diet Flavonoid Green Tea Machine Learning Metabolites Physiology Public Health Research Social Care Supplements Tea
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