Researchers review the association between endogenous retrovirus reactivation and aging sbpdiscovery EndogenousRetrovirus Aging AntiAging
By Pooja Toshniwal PahariaJan 24 2023Reviewed by Aimee Molineux In a recent review published in Cell, researchers explored the role of endogenous retrovirus reactivation in the aging process.
ERV reactivation and aging ERV reactivation during advanced age could induce senescence, associated with epigenetic activation, and contribute to age-related chronic inflammatory responses. The endogenous retrovirus-K is reportedly the most recently integrated ERV that was incorporated into the genome of humans six million years ago.
Studies have reported that SASP factors be involved in age-related disorder development, tissue injury, and cellular degeneration. Retro-transposons, such as L1 , reportedly drive senescence-related and age-related processes. In addition to L1, HERVK RVLPs get activated by epigenetic derepression at senescence.
On release from cells that deteriorated with age or obtained from sera of elder individuals, particles of the human ERV-K could infect cells via envelope proteins and stimulate the generation of innate immunological responses among infected cells, resulting in senescence phenotype development. RVLP-secreting cells may either become senescent, or the infected cells may release senescence-inducing factors among adjacent cells.
Future perspectives The activities of HERVs in healthy tissues and the pathways involved in promoting aging by ERV have not been well-characterized. In addition, the pathways of L1-mediated interferon activation and HERVK-mediated SASP activation need to be determined. Further research must be conducted to evaluate the therapeutic efficacy of NRTI drugs against HERVK-related and L1-related deterioration and senescence-related inflammation.
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