Researchers shed light on role of Tip60enzyme in genetic disruptions that cause Alzheimer's disease sfnjournals
to generate different functional variants of the same protein using a process known as alternative RNA splicing.
The team led by Akanksha Bhatnagar, a Ph.D. student, and Felice Elefant, Ph.D., a professor, who are biology researchers in Drexel's College of Arts and Sciences, is the first to uncover the role of the Tip60 enzyme in binding to certain RNA in the brain to control how they are spliced. "We have previously shown that Tip60 enzyme levels are depleted in Alzheimer's disease brains and this depletion results in some genes getting inactivated. However, with this new RNA splicing function, we now show Tip60 is also not present to bind to the RNA to allow for appropriate splicing in the brain and may be causing some of the splicing defects observed in Alzheimer's disease," said Elefant.
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