Researchers use a comparative study to model RSV prevention in children elsevierconnect UAntwerpen RSV Children ComparativeStudy
By Dr. Liji Thomas, MDNov 28 2022Reviewed by Aimee Molineux Now that the coronavirus disease 2019 pandemic has been around for almost three years, scientists are looking at other resurgent respiratory viruses that are taking a heavy toll on human health following the removal of mask-related and other public health protections against virus transmission. Among these viruses is the respiratory syncytial virus .
Several models have been introduced to study the cost-effectiveness of preventive programs for RSV but are limited by restricted data and varying results. This study aimed to produce modeling estimates using the same data and assumptions from several models. The resulting outcomes could be compared with greater utility than those from differing studies.
What did the study show? With the static models, approximately one thousand cases were estimated to be averted by the maternal vaccine, amounting to a direct saving of a million pounds in medical costs and a third more in non-medical costs. Simultaneously, babies less than a year old were estimated to have gained 4-5 discounted QALYs, for each year of intervention.
The former model did not assume the waning of vaccine-induced protection in infants after three months and showed this age shift in peak cases. It also showed that non-severe hospitalizations dropped to about a third at 3-5 months with mAb use, while those requiring primary care dropped by half.
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