Alopecia, dysesthesia, and other types of skin sensations have been reported in patients treated with semaglutide, but more research is needed to understand skin findings associated with this drug.
A review of 22 articles found a higher incidence of "altered skin sensations" and alopecia in individuals receiving oral semaglutide than in those receiving placebo.has not received reports of semaglutide-related safety events, and few studies have characterized skin findings associated with oral or subcutaneous semaglutide, a glucagon-like peptide 1 agonist used to treat obesity and type 2 diabetes.
In this scoping review, researchers included 22 articles , published through January 2024, of patients receiving either semaglutide or a placebo or comparator, which included reports of semaglutide-associated adverse dermatologic events in 255 participants.Patients who received 50 mg oral semaglutide weekly reported a higher incidence of altered skin sensations, such as dysesthesia , hyperesthesia , skin pain , paresthesia , and sensitive skin , than those receiving placebo or comparator.
Reports of alopecia were higher in patients who received 50 mg oral semaglutide weekly than in those on placebo, but only 0.2% of patients on 2.4 mg of subcutaneous semaglutide reported alopecia vs 0.5% of those on placebo. Unspecified dermatologic reactions were reported in more patients on subcutaneous semaglutide than those on a placebo or comparator. Several case reports described isolated cases of severe skin-related adverse effects, such as bullous pemphigoid, eosinophilic fasciitis, and leukocytoclastic vasculitis.
On the contrary, injection site reactions were less common in patients on subcutaneous semaglutide compared with in those on a placebo or comparator."Variations in dosage and administration routes could influence the types and severity of skin findings, underscoring the need for additional research," the authors wrote.Megan M.
Adverse Effects Side Effects Bullous Pemphigoid Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study Double-Blind Studies Single-Blind Study Single-Blind Studies Eosinophilic Fasciitis Hypersensitivity Vasculitis Leukocytoclastic Vasculitis Hypersensitivity Angiitis Leucocytoclastic Vasculitis Pain Paresthesia Rhode Island Vasculitis
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